Halfway by his profession, Cees Dekker reinvented himself. After years of hardcore physics, he shifted his emphasis to ‘nanobiology’ in the convert from the millennium. A expression he coined himself, as being a subject of reality.

Our team experiments bacterial mobile division and is also aiming to constitute a ‘base up biology’ in artificial cells that could autonomously divide. Our principal curiosity lies in mobile division, chromatin framework, and spatial Handle.

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Regrettably, for years immediately after Iijima’s report, the production of clean up nanotubes was cumbersome. In 1996, nonetheless, the team of Richard Smalley at Rice University managed to make single-walled carbon nanotubes at significant yield. Shortly just after, I contacted Smalley, and we decided to be part of forces to evaluate the transport by way of a one carbon nanotube.

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Immediate immobilization of native yeast iso-one cytochrome c on bare gold: quickly electron relay to redox enzymes and zeptomole protein-movie voltammetry

Given that 2000 he moved to single-molecule biophysics and nanobiology, with research from DNA supercoiling studies of nucleosomes and DNA maintenance proteins to DNA translocation by nanopores. Not long ago his investigation has focused on researching cell division with bacteria on chip, though his supreme curiosity is in the course of acknowledging artificial cells.

Atomic pressure microscopy reveals that vaccinia topoisomerase IB generates filaments on DNA inside a cooperative vogue

Comprehension elementary procedures regulating the spatial and dynamic organisation on the DNA in Stay cells.

Dekker begun his exploration on single carbon nanotubes in 1993 when he arrange a different line of investigation to study electrical transportation by means of one organic and natural molecules in between nanoelectrodes. In 1996 a breakthrough was understood with carbon nanotubes. This was reached inside a collaboration While using the group of Nobel laureate Richard Smalley. STM and nanolithography techniques ended up used to exhibit that these nanotubes are quantum wires at The one-molecule degree, with outstanding Bodily properties.

Considering the fact that 2000 he moved to solitary-molecule biophysics and nanobiology, with ceesdekker study from experiments of DNA loop extrusion and supercoiling to DNA translocation by way of nanopores. Much more a short while ago his investigation has focused on finding out chromatin structure and mobile division with bacteria on chip, when he is additionally seeking to in the end build synthetic cells from The underside up.

2006, 1st demonstration of molecular sorting inside of a lab on a chip employing biomotors; discovery of nanobubbles in good-state nanopores; and very first estimate of electrokinetic Electricity conversion in a nanofluidic channel

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Good-point out nanopores have confirmed to become a astonishingly adaptable probe for solitary-molecule Examination of DNA. I will describe a few of our current findings – particularly DNA knots – in addition to our attempts to broaden the capabilities of solid-point out nanopores even further more, during the way of one-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.